
Luis Marín
Centre-back · Liga Deportiva Alajuelense
- born
- 1974
- apps
- 650
- goals
- 25
- caps
- 128
2Maxi Pereira
Full-back · Club Atlético River Plate
- born
- 1984
- apps
- 617
- goals
- 46
- caps
- 125
Gonzalo Castro Irizábal
Central midfielder · Club Atlético River Plate
- born
- 1984
- apps
- 571
- goals
- 79
- caps
- 5
3Carlos Sánchez
Midfielder · Real Madrid
- born
- 1986
- apps
- 567
- goals
- 16
- caps
- 88

Gus Poyet
Midfielder · Montevideo Wanderers Fútbol Club
- born
- 1967
- apps
- 536
- goals
- 151
- caps
- 32
Carlos María Morales
Forward · Montevideo Wanderers Fútbol Club
- born
- 1970
- apps
- 535
- goals
- 207
- caps
- 7

Daniel Passarella
Centre-back · Club Atlético River Plate
- born
- 1953
- apps
- 517
- goals
- 165
- caps
- 70
Iván Alonso
Forward · Club Atlético River Plate
- born
- 1979
- apps
- 490
- goals
- 164
- caps
- –
Luis Diego López
Defender · Cagliari Calcio
- born
- 1974
- apps
- 482
- goals
- 14
- caps
- 39
9Hernán Rodrigo López
Forward · Club Guaraní
- born
- 1978
- apps
- 459
- goals
- 175
- caps
- 2
Gabriel Cedrés
Forward · Deportivo Maldonado
- born
- 1970
- apps
- 450
- goals
- 95
- caps
- 28
Santiago Silva
Forward · Club Atlético Banfield
- born
- 1980
- apps
- 443
- goals
- 159
- caps
- –

Giancarlo Maldonado
Forward · Internacional de Bogotá
- born
- 1982
- apps
- 442
- goals
- 172
- caps
- 64
Gustavo Biscayzacú
Forward · Boston River
- born
- 1978
- apps
- 412
- goals
- 193
- caps
- –
Cristian González Aidinovich
Defender · Club Atlético River Plate
- born
- 1976
- apps
- 384
- goals
- 14
- caps
- 8

Fernando Morena
Forward · Club Atlético Peñarol
- born
- 1952
- apps
- 369
- goals
- 295
- caps
- 53
Fernando Correa
Forward · Club Atlético River Plate
- born
- 1974
- apps
- 368
- goals
- 102
- caps
- 15
Gabriel Correa
Midfielder · Hércules CF
- born
- 1968
- apps
- 366
- goals
- 19
- caps
- 26
Deivis Barone
Defender · San Martín de San Juan
- born
- 1979
- apps
- 354
- goals
- 33
- caps
- –
Carlos Aguilera
Forward · Club Atlético Peñarol
- born
- 1964
- apps
- 342
- goals
- 118
- caps
- 78
Carlos Eduardo Gutiérrez
Defender · C.A. Bella Vista
- born
- 1976
- apps
- 335
- goals
- 2
- caps
- 5
Brian Diego Fuentes
Forward · Asociación Deportiva Berazategui
- born
- 1976
- apps
- 332
- goals
- 293
- caps
- –
activeMatías Alonso Vallejo
Forward · The Strongest
- age
- 41
- apps
- 325
- goals
- 88
- caps
- 4
Diego Roberto Sosa
Defender · Deportivo Español
- born
- 1980
- apps
- 324
- goals
- 9
- caps
- –
Alexander Medina
Forward · Centro Atlético Fénix
- born
- 1978
- apps
- 322
- goals
- 113
- caps
- 1
Pablo Granoche
Forward · Modena F.C.
- born
- 1983
- apps
- 307
- goals
- 112
- caps
- 1
Juan Ramón Curbelo
Midfielder · Boston River
- born
- 1979
- apps
- 305
- goals
- 19
- caps
- 4
Nelson Abeijón
Midfielder · Club Atlético River Plate
- born
- 1973
- apps
- 305
- goals
- 25
- caps
- 23
Esteban Guillén
Midfielder · Persiba Balikpapan
- born
- 1980
- apps
- 301
- goals
- 26
- caps
- –

Severino Varela
Forward · Sud América
- born
- 1913
- apps
- 299
- goals
- 194
- caps
- 24

Ettore Puricelli
Forward · A.C. Legnano
- born
- 1916
- apps
- 292
- goals
- 168
- caps
- 1
Gonzalo Porras
Midfielder · Club Nacional de Football
- born
- 1984
- apps
- 286
- goals
- 10
- caps
- –
Edgardo Adinolfi
Defender · Olympiakos Nicosia FC
- born
- 1974
- apps
- 285
- goals
- 11
- caps
- 24

André Luiz Rodrigues Lopes
Midfielder · Phuket F.C.
- born
- 1985
- apps
- 282
- goals
- 48
- caps
- –
Williams Martínez
Defender · Internacional de Bogotá
- born
- 1982
- apps
- 269
- goals
- 12
- caps
- 1
Alexis Viera
Goalkeeper · Club Atlético River Plate
- born
- 1978
- apps
- 267
- goals
- 8
- caps
- –
Alejandro Mello
Forward · Deportivo Maldonado
- born
- 1979
- apps
- 264
- goals
- 79
- caps
- –

Carlos Diogo
Defender · Real Zaragoza
- born
- 1983
- apps
- 263
- goals
- 14
- caps
- 24
Osvaldo Canobbio
Forward · Centro Atlético Fénix
- born
- 1973
- apps
- 257
- goals
- 60
- caps
- 8
activeWalter Alberto López
Defender · Benevento Calcio
- age
- 41
- apps
- 252
- goals
- 18
- caps
- 3
Claudio Dadómo
Defender · El Tanque Sisley
- born
- 1982
- apps
- 250
- goals
- 29
- caps
- 3
4activeJorge Marcelo Rodríguez
Midfielder · Club Atlético Tigre
- age
- 41
- apps
- 248
- goals
- 36
- caps
- 5

Eusebio Tejera
Defender · Club Nacional de Football
- born
- 1922
- apps
- 247
- goals
- 1
- caps
- 31
Jorge Curbelo
Centre-back · Arsenal Fútbol Club
- born
- 1981
- apps
- 246
- goals
- 16
- caps
- 1
Sebastián Taborda
Forward · Club Nacional de Football
- born
- 1981
- apps
- 246
- goals
- 71
- caps
- 1
Andreé González
Defender · Zulia FC
- born
- 1975
- apps
- 245
- goals
- 23
- caps
- 17
activeGiovanni González
Defender · RCD Mallorca
- age
- 32
- apps
- 245
- goals
- 10
- caps
- 16
Hebert Revetria
Forward · Club Atlético River Plate
- born
- 1955
- apps
- 244
- goals
- 99
- caps
- 19