Jorge Orosmán da Silva
Forward · Defensor Sporting Club
- born
- 1961
- apps
- 502
- goals
- 180
- caps
- 41
Martín Ligüera
Midfielder · Centro Atlético Fénix
- born
- 1980
- apps
- 404
- goals
- 122
- caps
- 17
Javier Cámpora
Forward · G.A.S. Veria
- born
- 1980
- apps
- 387
- goals
- 119
- caps
- –
Adrián Berbia
Goalkeeper · Boston River
- born
- 1977
- apps
- 386
- goals
- 0
- caps
- 2
José Cancela
Midfielder · C.S. Herediano
- born
- 1976
- apps
- 375
- goals
- 67
- caps
- –
William Ferreira
Forward · Club Bolívar
- born
- 1983
- apps
- 363
- goals
- 168
- caps
- 1
18Alejandro Lago
Defender · C.A. Progreso
- born
- 1979
- apps
- 354
- goals
- 7
- caps
- 16
Christian Callejas
Midfielder · Durazno FC
- born
- 1978
- apps
- 350
- goals
- 25
- caps
- 21
Leonel Pilipauskas
Defender · Boston River
- born
- 1975
- apps
- 339
- goals
- 11
- caps
- 4
Alexander Medina
Forward · Centro Atlético Fénix
- born
- 1978
- apps
- 322
- goals
- 113
- caps
- 1
Vladas Douksas
Forward · Club Atlético Colón
- born
- 1933
- apps
- 308
- goals
- 53
- caps
- 33
Nicolás Vigneri
Central midfielder · Huracán Football Club
- born
- 1983
- apps
- 307
- goals
- 81
- caps
- 22
Juan Ramón Curbelo
Midfielder · Boston River
- born
- 1979
- apps
- 305
- goals
- 19
- caps
- 4
Fabián Canobbio
Midfielder · Danubio F.C.
- born
- 1980
- apps
- 300
- goals
- 61
- caps
- 13
Gabriel Álvez
Forward · El Tanque Sisley
- born
- 1974
- apps
- 296
- goals
- 87
- caps
- 8
Fernando Fajardo
Defender · C.A. Progreso
- born
- 1975
- apps
- 289
- goals
- 18
- caps
- –
Edgardo Adinolfi
Defender · Olympiakos Nicosia FC
- born
- 1974
- apps
- 285
- goals
- 11
- caps
- 24
Marcelo Otero
Forward · Huracán Football Club
- born
- 1971
- apps
- 284
- goals
- 97
- caps
- 25
Paolo Suárez
Forward · C.D. Sonsonate
- born
- 1980
- apps
- 275
- goals
- 117
- caps
- 15
Nelson Barahona
Midfielder · Alianza Petrolera F.C.
- age
- 39
- apps
- 269
- goals
- 31
- caps
- 11
Víctor López
Forward · Centro Atlético Fénix
- born
- 1971
- apps
- 269
- goals
- 39
- caps
- 8
Marcelo Saralegui
Midfielder · Atlético Madrid
- born
- 1971
- apps
- 264
- goals
- 48
- caps
- 33
Osvaldo Canobbio
Forward · Centro Atlético Fénix
- born
- 1973
- apps
- 257
- goals
- 60
- caps
- 8
Álvaro Adrián Núñez
Goalkeeper · Club Deportivo Guadalajara
- born
- 1973
- apps
- 256
- goals
- 0
- caps
- 1
Richard Morales
Forward · Centro Atlético Fénix
- born
- 1975
- apps
- 256
- goals
- 87
- caps
- 27
4activeJorge Marcelo Rodríguez
Midfielder · Club Atlético Tigre
- age
- 41
- apps
- 248
- goals
- 36
- caps
- 5
Marcelo Broli
Midfielder · Miramar Misiones
- born
- 1978
- apps
- 248
- goals
- 12
- caps
- 2
Julio César Cortés
Midfielder · AD Guanacasteca
- born
- 1941
- apps
- 246
- goals
- 26
- caps
- 30
Sebastián Taborda
Forward · Club Nacional de Football
- born
- 1981
- apps
- 246
- goals
- 71
- caps
- 1
Andreé González
Defender · Zulia FC
- born
- 1975
- apps
- 245
- goals
- 23
- caps
- 17
Matías Acuña
Forward · Mushuc Runa Sporting Club
- age
- 34
- apps
- 238
- goals
- 63
- caps
- –
Claudio Rivero
Midfielder · Centro Atlético Fénix
- age
- 41
- apps
- 235
- goals
- 5
- caps
- –
Diego Guastavino
Forward · Club Universitario de Deportes
- born
- 1984
- apps
- 235
- goals
- 54
- caps
- –
Bryan Aldave
Forward · Central Español
- born
- 1983
- apps
- 228
- goals
- 52
- caps
- –
10Carlos Grossmüller
Midfielder · Danubio F.C.
- born
- 1983
- apps
- 227
- goals
- 35
- caps
- 6
Óscar Tabárez
Defender · C.A. Bella Vista
- born
- 1947
- apps
- 216
- goals
- 4
- caps
- –
Henry Damián Giménez
Forward · Mushuc Runa Sporting Club
- age
- 40
- apps
- 210
- goals
- 43
- caps
- 2
3activeMiguel Britos
Defender · Watford F.C.
- age
- 41
- apps
- 210
- goals
- 11
- caps
- –
Walter Ibáñez Martinez
Defender · Club Alianza Lima
- born
- 1984
- apps
- 209
- goals
- 23
- caps
- –
Marcelo Méndez
Centre-back · Huracán Football Club
- born
- 1981
- apps
- 206
- goals
- 11
- caps
- –
Julio Pablo Rodríguez
Midfielder · Real C.D. España
- born
- 1977
- apps
- 205
- goals
- 28
- caps
- 1
Martín Barlocco
Goalkeeper · Deportivo Maldonado
- born
- 1977
- apps
- 204
- goals
- 0
- caps
- –
Gonzalo Gutiérrez
Forward · C.A. Bella Vista
- born
- 1981
- apps
- 203
- goals
- 82
- caps
- –
Nicolás Vikonis
Goalkeeper · Talleres de Córdoba
- born
- 1984
- apps
- 203
- goals
- 0
- caps
- –
Richard Pellejero
Midfielder · C.A. Cerro
- born
- 1976
- apps
- 192
- goals
- 5
- caps
- –
19activeMauro Guevocian
Forward · Atlético Bucaramanga
- age
- 40
- apps
- 188
- goals
- 83
- caps
- 2
Peregrino Anselmo
Forward · Uruguay men's
- born
- 1902
- apps
- 188
- goals
- 105
- caps
- 8
Raúl Ferro
Midfielder · Centro Atlético Fénix
- born
- 1983
- apps
- 188
- goals
- 4
- caps
- –