18activeNemanja Matić
Defensive midfielder · US Sassuolo Calcio
- age
- 38
- apps
- 614
- goals
- 27
- caps
- 60

Matteo Brighi
Midfielder · Empoli FC
- born
- 1981
- apps
- 549
- goals
- 37
- caps
- 47
Amerigo Paradiso
Forward · U.S. Canzese
- born
- 1962
- apps
- 530
- goals
- 163
- caps
- –
Marco Schenardi
Position unrecorded · A.S.D. Narnese Calcio
- born
- 1968
- apps
- 529
- goals
- 45
- caps
- –

Paolo Bianco
Defender · US Sassuolo Calcio
- born
- 1977
- apps
- 527
- goals
- 13
- caps
- 1
15Francesco Acerbi
Centre-back · Inter Milan
- born
- 1988
- apps
- 516
- goals
- 30
- caps
- 35
Cosimo Francioso
Position unrecorded · A.D.C. Ars et Labor Grottaglie
- born
- 1967
- apps
- 502
- goals
- 208
- caps
- –
24activeFilip Đuričić
Forward · APOEL F.C.
- age
- 34
- apps
- 494
- goals
- 75
- caps
- 99
7Kevin-Prince Boateng
Forward · Hertha BSC
- born
- 1987
- apps
- 487
- goals
- 75
- caps
- 45

Alberto Aquilani
Midfielder · UD Las Palmas
- born
- 1984
- apps
- 478
- goals
- 48
- caps
- 115
Salvatore Bruno
Forward · A.S. Giana Erminio
- born
- 1979
- apps
- 478
- goals
- 145
- caps
- 2
Paolo Mandelli
Forward · US Sassuolo Calcio
- born
- 1967
- apps
- 462
- goals
- 55
- caps
- –
32Alessandro Matri
Forward · Brescia Calcio
- born
- 1984
- apps
- 453
- goals
- 127
- caps
- 7
Rosario Biondo
Defender · Mantova 1911
- born
- 1966
- apps
- 439
- goals
- 22
- caps
- –
Pier Antonio Torroni
Position unrecorded · US Sassuolo Calcio
- born
- 1963
- apps
- 435
- goals
- 3
- caps
- –

Piergiorgio Negrisolo
Defender · US Sassuolo Calcio
- born
- 1950
- apps
- 434
- goals
- 22
- caps
- 6
Andrea Mazzaferro
Midfielder · S.S.D. Jesina Calcio
- born
- 1966
- apps
- 432
- goals
- 15
- caps
- –
Andy Selva
Forward · S.P. La Fiorita
- born
- 1976
- apps
- 428
- goals
- 143
- caps
- 1
activeAleandro Rosi
Full-back · SS Lazio
- age
- 39
- apps
- 426
- goals
- 15
- caps
- 29
activeJasmin Kurtić
Midfielder · F.C. Südtirol
- age
- 37
- apps
- 426
- goals
- 56
- caps
- 2
Marco Giandebiaggi
Position unrecorded · Suzzara Calcio 2000
- born
- 1969
- apps
- 426
- goals
- 40
- caps
- –
16Andrea Poli
Midfielder · Pro Sesto 1913
- born
- 1989
- apps
- 425
- goals
- 24
- caps
- 40
Marco Piccioni
Defender · SS Lazio
- born
- 1976
- apps
- 424
- goals
- 16
- caps
- –
Riccardo Zampagna
Forward · Carrarese Calcio
- born
- 1974
- apps
- 421
- goals
- 150
- caps
- –
Giancarlo Corradini
Defender · SSC Napoli
- born
- 1961
- apps
- 420
- goals
- 10
- caps
- –

Horacio Erpen
Midfielder · Carrarese Calcio
- born
- 1981
- apps
- 419
- goals
- 70
- caps
- –
99Sergio Floccari
Forward · Bologna F.C. 1909
- born
- 1981
- apps
- 416
- goals
- 90
- caps
- 0

Massimiliano Benassi
Goalkeeper · S.S. Arezzo
- born
- 1981
- apps
- 414
- goals
- 159
- caps
- –
Massimo Pellegrini
Midfielder · Associazione Calcio Dilettantistica Poggese
- born
- 1966
- apps
- 414
- goals
- 60
- caps
- –
Alessandro Pane
Position unrecorded · Catania FC
- born
- 1967
- apps
- 411
- goals
- 22
- caps
- –

Tiziano Polenghi
Defender · A.S. Giana Erminio
- born
- 1978
- apps
- 404
- goals
- 18
- caps
- –
Emiliano Salvetti
Midfielder · Forlì F.C.
- born
- 1974
- apps
- 401
- goals
- 71
- caps
- 1
28Paolo Cannavaro
Centre-back · US Sassuolo Calcio
- born
- 1981
- apps
- 400
- goals
- 13
- caps
- 30
Marco Bizzarri
Position unrecorded · Rimini FC
- born
- 1967
- apps
- 397
- goals
- 312
- caps
- –
11Gianni Munari
Midfielder · Cagliari Calcio
- born
- 1983
- apps
- 387
- goals
- 37
- caps
- –

Vlad Chiricheș
Defensive midfielder · FCSB
- born
- 1989
- apps
- 380
- goals
- 9
- caps
- 82
Luigi Riccio
Midfielder · US Sassuolo Calcio
- born
- 1977
- apps
- 379
- goals
- 24
- caps
- –
Paolo Sacchetti
Position unrecorded · S.S.D. Castel San Pietro Terme Calcio
- born
- 1965
- apps
- 379
- goals
- 30
- caps
- –
99activeAntonio Sanabria
Forward · S.C. Internacional
- age
- 30
- apps
- 378
- goals
- 84
- caps
- 63
Dario Morello
Forward · G.S. Bagnolese
- born
- 1968
- apps
- 372
- goals
- 46
- caps
- –
Mauro Rabitti
Midfielder · US Sassuolo Calcio
- born
- 1958
- apps
- 370
- goals
- 69
- caps
- –
83Antonio Floro Flores
Forward · AC ChievoVerona
- born
- 1983
- apps
- 369
- goals
- 96
- caps
- 16
activeDuje Ćaleta-Car
Centre-back · US Sassuolo Calcio
- age
- 30
- apps
- 369
- goals
- 22
- caps
- 66

Antonio Bocchetti
Defender · U.S. Salernitana 1919
- born
- 1980
- apps
- 367
- goals
- 6
- caps
- 5

Gennaro Troianiello
Forward · Ternana Calcio
- born
- 1983
- apps
- 367
- goals
- 91
- caps
- –
Davide Biondini
Midfielder · US Sassuolo Calcio
- born
- 1983
- apps
- 363
- goals
- 11
- caps
- 7
Silvio Formentin
Midfielder · US Sassuolo Calcio
- born
- 1922
- apps
- 363
- goals
- 82
- caps
- –
21Carl Valeri
Midfielder · Melbourne Victory FC
- born
- 1984
- apps
- 361
- goals
- 17
- caps
- 13