93Sergio Ramos
Centre-back · Club de Fútbol Monterrey
- born
- 1986
- apps
- 801
- goals
- 110
- caps
- 193
10Walter Ayoví
Midfielder · Guayaquil City F.C.
- born
- 1979
- apps
- 754
- goals
- 73
- caps
- 121
Juan Arango
Midfielder · Zulia FC
- born
- 1980
- apps
- 751
- goals
- 167
- caps
- 137

Oribe Peralta
Forward · C.D. Guadalajara
- born
- 1984
- apps
- 659
- goals
- 216
- caps
- 81
11activeHugo Rodallega
Forward · Independiente Santa Fe
- age
- 41
- apps
- 650
- goals
- 251
- caps
- 55
8Osvaldo Martínez
Midfielder · Sportivo Luqueño
- born
- 1986
- apps
- 645
- goals
- 99
- caps
- 32

Carlos Hermosillo
Forward · C.D. Guadalajara
- born
- 1964
- apps
- 629
- goals
- 346
- caps
- 90
15Héctor Moreno
Centre-back · Club de Fútbol Monterrey
- born
- 1988
- apps
- 629
- goals
- 38
- caps
- 142
27Luis Ernesto Pérez
Midfielder · Club de Fútbol Monterrey
- born
- 1981
- apps
- 622
- goals
- 70
- caps
- 69

Jared Borgetti
Forward · Club León
- born
- 1973
- apps
- 614
- goals
- 315
- caps
- 89

Sebastián Abreu
Forward · Central Español
- born
- 1976
- apps
- 613
- goals
- 303
- caps
- 70
3Felipe Baloy
Defender · C.S.D. Municipal
- born
- 1981
- apps
- 597
- goals
- 36
- caps
- 102
8Carlos Sánchez
Central midfielder · C.A. Rentistas
- born
- 1984
- apps
- 594
- goals
- 94
- caps
- 38
Alfonso Sosa
Midfielder · Querétaro F.C.
- born
- 1967
- apps
- 578
- goals
- 27
- caps
- 14
Duilio Davino
Centre-back · Tecos F.C.
- born
- 1976
- apps
- 574
- goals
- 19
- caps
- 85

Ricardo Ferretti
Midfielder · Pumas UNAM
- born
- 1954
- apps
- 567
- goals
- 202
- caps
- –
Marcelino Bernal
Midfielder · Pumas UNAM
- born
- 1962
- apps
- 560
- goals
- 88
- caps
- 64
Ramón Morales
Midfielder · Tecos F.C.
- born
- 1975
- apps
- 558
- goals
- 76
- caps
- 64
20activeSergio Canales Madrazo
Midfielder · Racing de Santander
- age
- 35
- apps
- 546
- goals
- 107
- caps
- 50
Giovanny Espinoza
Centre-back · S.D. Quito
- born
- 1977
- apps
- 542
- goals
- 19
- caps
- 90

Miguel Ramírez
Defender · Club Social y Deportivo Colo-Colo
- born
- 1970
- apps
- 538
- goals
- 39
- caps
- 62
Missael Espinoza
Midfielder · Cruz Azul
- born
- 1965
- apps
- 534
- goals
- 91
- caps
- 41

Manuel Negrete Arias
Midfielder · Atlante F.C.
- born
- 1959
- apps
- 522
- goals
- 125
- caps
- 57

Miguel Layún
Full-back · Club América
- born
- 1988
- apps
- 508
- goals
- 35
- caps
- 71

Luis Hernández
Forward · Lobos de la BUAP
- born
- 1968
- apps
- 501
- goals
- 174
- caps
- 85
Juan Hernández
Defender · Atlante F.C.
- born
- 1965
- apps
- 500
- goals
- 22
- caps
- 36
13Alexander Mejía
Midfielder · Deportivo Cali
- born
- 1988
- apps
- 498
- goals
- 5
- caps
- 27

Eusébio
Forward · New Jersey Americans
- born
- 1942
- apps
- 495
- goals
- 464
- caps
- 64
Mario Méndez
Defender · San Luis F.C.
- born
- 1979
- apps
- 490
- goals
- 18
- caps
- 37
Guillermo Rivarola
Defender · Racing Club
- born
- 1968
- apps
- 486
- goals
- 32
- caps
- –

Antonio Mohamed
Forward · ACF Fiorentina
- born
- 1970
- apps
- 484
- goals
- 127
- caps
- 6
26Humberto Suazo
Forward · Club Deportes La Serena
- born
- 1981
- apps
- 473
- goals
- 283
- caps
- 60
Roberto Gasparini
Midfielder · Estudiantes de Río Cuarto
- born
- 1958
- apps
- 469
- goals
- 140
- caps
- –
Alberto Rodríguez
Defender · Cruz Azul Hidalgo
- born
- 1974
- apps
- 468
- goals
- 11
- caps
- 13
7activeLucas Ocampos
Central midfielder · Club de Fútbol Monterrey
- age
- 32
- apps
- 463
- goals
- 81
- caps
- 24
26activeIván Piris
Full-back · Deportivo Recoleta
- age
- 37
- apps
- 453
- goals
- 3
- caps
- 52
9Sergio Santana
Forward · Mineros de Zacatecas
- born
- 1979
- apps
- 451
- goals
- 81
- caps
- –
Daniel Osorno
Central midfielder · Correcaminos UAT
- born
- 1979
- apps
- 442
- goals
- 83
- caps
- 62
José Antonio Noriega
Midfielder · Club Atlético Morelia
- born
- 1969
- apps
- 441
- goals
- 54
- caps
- 6
Paulo Chávez
Midfielder · Dorados de Sinaloa
- born
- 1976
- apps
- 440
- goals
- 81
- caps
- 30
6Ricardo Osorio
Full-back · Querétaro F.C.
- born
- 1980
- apps
- 440
- goals
- 3
- caps
- 82
José Luis Salgado
Defender · Club Atlético Morelia
- born
- 1966
- apps
- 439
- goals
- 12
- caps
- 3
Carlos Casartelli
Forward · Deportivo Mandiyú
- born
- 1974
- apps
- 429
- goals
- 140
- caps
- –
Juan de Dios Ramírez Perales
Defender · Tiburones Rojos de Veracruz
- born
- 1969
- apps
- 429
- goals
- 1
- caps
- 49
Octavio Valdez
Defender · C.F. La Piedad
- born
- 1973
- apps
- 429
- goals
- 24
- caps
- 30
Roberto Medina
Defender · CD Zacatepec
- born
- 1968
- apps
- 428
- goals
- 28
- caps
- 6
19César Delgado
Forward · Club Atlético Rosario Central
- born
- 1981
- apps
- 425
- goals
- 109
- caps
- 33
José Manuel Abundis
Forward · Querétaro F.C.
- born
- 1973
- apps
- 418
- goals
- 114
- caps
- 47