
José Luis Chilavert
Goalkeeper · Club Atlético Vélez Sarsfield
- born
- 1965
- apps
- 791
- goals
- 67
- caps
- 74

Virginio Cáceres
Defender · Club Olimpia
- born
- 1962
- apps
- 602
- goals
- 74
- caps
- 45
Francisco Esteche
Midfielder · Club General Caballero
- born
- 1973
- apps
- 538
- goals
- 100
- caps
- 22

Rubén Maldonado
Defender · Club Nacional
- born
- 1979
- apps
- 506
- goals
- 30
- caps
- 16
Ever Hugo Almeida
Goalkeeper · Club Olimpia
- born
- 1948
- apps
- 460
- goals
- 0
- caps
- 22
9Hernán Rodrigo López
Forward · Club Guaraní
- born
- 1978
- apps
- 459
- goals
- 175
- caps
- 2
Julián Benítez
Forward · Club Olimpia
- age
- 39
- apps
- 439
- goals
- 108
- caps
- –
Adriano Samaniego
Forward · Club Guaraní
- born
- 1963
- apps
- 437
- goals
- 185
- caps
- 26
Jorge Martín Núñez
Full-back · Club General Caballero
- born
- 1978
- apps
- 411
- goals
- 24
- caps
- 23
Jonathan Fabbro
Midfielder · Cerro Porteño
- born
- 1982
- apps
- 410
- goals
- 113
- caps
- –
Julio Manzur
Centre-back · Club Rubio Ñu
- born
- 1981
- apps
- 401
- goals
- 22
- caps
- 32
Víctor Hugo Ávalos
Midfielder · Club Silvio Pettirossi
- born
- 1971
- apps
- 394
- goals
- 17
- caps
- 5
César Cáceres Cañete
Midfielder · Club Nacional
- born
- 1977
- apps
- 387
- goals
- 81
- caps
- 2
10Salvador Cabañas
Forward · Tanabi Esporte Clube
- born
- 1980
- apps
- 382
- goals
- 184
- caps
- 49

Aureliano Torres
Central midfielder · Club 12 de Octubre
- born
- 1982
- apps
- 377
- goals
- 33
- caps
- –
Kenji Fukuda
Forward · Dreams Metro Gallery FC
- born
- 1977
- apps
- 377
- goals
- 102
- caps
- 4

Edgar Robles
Midfielder · Sportivo Luqueño
- born
- 1977
- apps
- 372
- goals
- 32
- caps
- 5
Rodrigo Teixeira
Forward · Club Nacional
- born
- 1978
- apps
- 361
- goals
- 85
- caps
- –
Osvaldo Hobecker
Central midfielder · Liga Deportiva Universitaria de Loja
- born
- 1984
- apps
- 340
- goals
- 56
- caps
- –
9Hernán Barcos
Forward · Bashundhara Kings
- born
- 1984
- apps
- 335
- goals
- 152
- caps
- –

Enrique Gabriel Meza
Defender · Club Sportivo San Lorenzo
- born
- 1985
- apps
- 334
- goals
- 11
- caps
- 2
Jorge Brítez
Midfielder · Club Rubio Ñu
- born
- 1981
- apps
- 327
- goals
- 27
- caps
- 2
Miguel Ángel Benítez
Forward · Club Guaraní
- born
- 1970
- apps
- 323
- goals
- 71
- caps
- 30
9Dante López
Forward · Pumas UNAM
- born
- 1983
- apps
- 321
- goals
- 67
- caps
- –
Juan Samudio
Forward · Sportivo Luqueño
- born
- 1978
- apps
- 317
- goals
- 143
- caps
- 13
Derlis Gómez
Goalkeeper · Club 12 de Octubre
- born
- 1972
- apps
- 311
- goals
- 0
- caps
- 6
Aldo Barreto
Forward · Sportivo Luqueño
- born
- 1981
- apps
- 308
- goals
- 161
- caps
- –
Carlos Santos
Forward · Club Atlético Central Norte
- born
- 1968
- apps
- 307
- goals
- 52
- caps
- 7
Ángel Ortiz
Midfielder · Independiente F.B.C.
- born
- 1977
- apps
- 306
- goals
- 10
- caps
- 27
Fernando Cafasso
Midfielder · Tiro al aire
- born
- 1983
- apps
- 305
- goals
- 23
- caps
- –

Sergio Órteman
Midfielder · Club Sportivo San Lorenzo
- born
- 1978
- apps
- 302
- goals
- 34
- caps
- –
Luis Núñez
Midfielder · Tacuary Football Club
- born
- 1980
- apps
- 290
- goals
- 12
- caps
- 2
Arnaldo Espínola
Defender · Club 12 de Octubre
- born
- 1975
- apps
- 289
- goals
- 9
- caps
- 3
Derlis Soto
Forward · Crucero del Norte Mutual Club
- born
- 1973
- apps
- 288
- goals
- 45
- caps
- 14

Gustavo Morínigo
Midfielder · Club Nacional
- born
- 1977
- apps
- 288
- goals
- 58
- caps
- 18
Juan Daniel Cáceres
Defender · Club Rubio Ñu
- born
- 1973
- apps
- 288
- goals
- 10
- caps
- 20
5Julio César Cáceres
Centre-back · Club Guaraní
- born
- 1979
- apps
- 281
- goals
- 13
- caps
- –
Pablo Aurrecochea
Goalkeeper · Club Atlético Atlanta
- born
- 1981
- apps
- 281
- goals
- 0
- caps
- –
Walter Guglielmone
Forward · Esporte Clube Pelotas
- born
- 1978
- apps
- 279
- goals
- 90
- caps
- 2
Edgar Daniel González
Midfielder · Cerro Porteño
- born
- 1979
- apps
- 272
- goals
- 19
- caps
- –
Miguel Ángel Paniagua
Midfielder · Club Olimpia
- age
- 39
- apps
- 269
- goals
- 15
- caps
- 1
Fabio Escobar
Forward · Club Deportivo Capiatá
- born
- 1982
- apps
- 266
- goals
- 63
- caps
- 4
Osvaldo Díaz
Midfielder · Club 12 de Octubre
- born
- 1981
- apps
- 263
- goals
- 39
- caps
- 5
Eufemio Cabral
Midfielder · Rio Ave F.C.
- born
- 1955
- apps
- 255
- goals
- 14
- caps
- 10
Elvis Marecos
Defender · Club 12 de Octubre
- born
- 1980
- apps
- 254
- goals
- 46
- caps
- 12
Luis Alberto Carranza
Forward · Club Almirante Brown
- born
- 1972
- apps
- 254
- goals
- 30
- caps
- 1
Pablo Giménez
Forward · Caacupé Football Club
- born
- 1981
- apps
- 242
- goals
- 57
- caps
- 2
Gilberto Velásquez
Defender · Tacuary Football Club
- born
- 1983
- apps
- 238
- goals
- 13
- caps
- 5