28activeFernando Muslera
Goalkeeper · Estudiantes de La Plata
- age
- 40
- apps
- 635
- goals
- 2
- caps
- 16
2Maxi Pereira
Full-back · Club Atlético River Plate
- born
- 1984
- apps
- 617
- goals
- 46
- caps
- 125

Cristian Rodríguez
Attacking midfielder · Plaza Colonia
- born
- 1985
- apps
- 505
- goals
- 74
- caps
- 119
Luis Diego López
Defender · Cagliari Calcio
- born
- 1974
- apps
- 482
- goals
- 14
- caps
- 39
4activeSebastián Coates
Centre-back · Club Nacional de Football
- age
- 36
- apps
- 438
- goals
- 30
- caps
- 74
2activeAlejandro Damián González
Full-back · Club Oriental de Fútbol
- age
- 38
- apps
- 423
- goals
- 6
- caps
- 7
7activeCristhian Stuani
Forward · Girona FC
- age
- 40
- apps
- 407
- goals
- 128
- caps
- 77
7Egidio Arévalo Rios
Midfielder · Atlas F.C.
- born
- 1982
- apps
- 373
- goals
- 24
- caps
- 1
18Alejandro Lago
Defender · C.A. Progreso
- born
- 1979
- apps
- 354
- goals
- 7
- caps
- 16
1Martín Silva
Goalkeeper · CR Vasco da Gama
- born
- 1983
- apps
- 311
- goals
- 1
- caps
- 18
Juan Ángel Albín
Midfielder · Tiburones Rojos de Veracruz
- age
- 40
- apps
- 306
- goals
- 90
- caps
- 4
Fabián Canobbio
Midfielder · Danubio F.C.
- born
- 1980
- apps
- 300
- goals
- 61
- caps
- 13
Sergio Leal
Forward · Plaza Colonia
- born
- 1982
- apps
- 297
- goals
- 82
- caps
- 3
26Fabián Carini
Goalkeeper · Juventud de Las Piedras
- born
- 1979
- apps
- 292
- goals
- 2
- caps
- 85
16activeDiego Rossi
Winger · Columbus Crew
- age
- 28
- apps
- 285
- goals
- 95
- caps
- 55
2Guillermo Daniel Rodríguez
Full-back · Club Atlético Peñarol
- born
- 1984
- apps
- 285
- goals
- 13
- caps
- 14
Emiliano Alfaro
Forward · Liverpool F.C. (Montevideo)
- born
- 1988
- apps
- 270
- goals
- 115
- caps
- 14
10Rubén Olivera
Midfielder · Latina Calcio 1932
- born
- 1983
- apps
- 250
- goals
- 39
- caps
- 24
Darío Flores
Centre-back · Club Atlético River Plate
- born
- 1984
- apps
- 232
- goals
- 14
- caps
- 1
Bryan Aldave
Forward · Central Español
- born
- 1983
- apps
- 228
- goals
- 52
- caps
- –
Junior Aliberti
Forward · Miramar Misiones
- born
- 1984
- apps
- 223
- goals
- 53
- caps
- 2
23activeDiego Polenta
Defender · LA Galaxy
- age
- 34
- apps
- 208
- goals
- 15
- caps
- 36

Nicolás Vikonis
Goalkeeper · Talleres de Córdoba
- born
- 1984
- apps
- 203
- goals
- 0
- caps
- –
Horacio Peralta
Forward · Club Sportivo Cerrito
- born
- 1982
- apps
- 198
- goals
- 28
- caps
- 11
4activeGary Kagelmacher
Centre-back · Maccabi Haifa F.C.
- age
- 38
- apps
- 197
- goals
- 15
- caps
- 7
Federico Magallanes
Forward · Racing de Santander
- born
- 1976
- apps
- 194
- goals
- 58
- caps
- 26
Jorge Ramírez
Forward · Guayaquil City F.C.
- age
- 40
- apps
- 189
- goals
- 51
- caps
- –
activeDamián Suárez
Defender · Getafe CF
- age
- 38
- apps
- 186
- goals
- 5
- caps
- 6
23activeSebastián Rivas
Forward · Club Atlético River Plate
- age
- 38
- apps
- 184
- goals
- 66
- caps
- 2
activeAdrián Seba Rey
Forward · Venados FC
- age
- 34
- apps
- 181
- goals
- 35
- caps
- 19
1activeSebastián Sosa
Goalkeeper · Uruguay
- age
- 40
- apps
- 181
- goals
- 0
- caps
- 6
Diego de Souza Carballo
Midfielder · Cerro Largo FC
- born
- 1984
- apps
- 176
- goals
- 35
- caps
- 3
Leandro Ezquerra
Midfielder · Racing Club de Montevideo
- age
- 40
- apps
- 174
- goals
- 21
- caps
- 1
Diego Rodríguez Da Luz
Midfielder · Club Atlético River Plate
- age
- 40
- apps
- 169
- goals
- 7
- caps
- –
Elías Ricardo Figueroa
Forward · El Tanque Sisley
- age
- 38
- apps
- 166
- goals
- 37
- caps
- 20
Fernando Carreño
Defender · Uruguay
- born
- 1979
- apps
- 160
- goals
- 13
- caps
- 11
Ramón Arias
Defender · Puebla F.C.
- age
- 34
- apps
- 159
- goals
- 7
- caps
- 47
23activeBruno Fornaroli Sevilla
Forward · Melbourne City FC
- age
- 39
- apps
- 151
- goals
- 50
- caps
- –
21activeDiego Arismendi
Midfielder · Al-Shabab Football Club
- age
- 38
- apps
- 149
- goals
- 12
- caps
- 3
Renzo Pozzi
Midfielder · Juventud de Las Piedras
- born
- 1984
- apps
- 145
- goals
- 8
- caps
- –
Jesús Benítez
Midfielder · Uruguay
- born
- 1984
- apps
- 137
- goals
- 16
- caps
- –
20activePablo Lavandeira
Midfielder · Club Universitario de Deportes
- age
- 36
- apps
- 127
- goals
- 17
- caps
- 1
Michel Acosta
Midfielder · Murciélagos F.C.
- age
- 38
- apps
- 123
- goals
- 13
- caps
- 3
27activeJonathan Urretaviscaya
Position unrecorded · CF Pachuca
- age
- 36
- apps
- 120
- goals
- 33
- caps
- –
Martín González
Defender · Atenas de San Carlos
- age
- 36
- apps
- 116
- goals
- 1
- caps
- –
activeFrancisco Usúcar
Midfielder · Atenas de San Carlos
- age
- 40
- apps
- 115
- goals
- 3
- caps
- 18
Marcel Román
Midfielder · Oriente Petrolero
- age
- 38
- apps
- 114
- goals
- 3
- caps
- 15
8activeFederico Valverde
Midfielder · Real Madrid Club de Fútbol
- age
- 28
- apps
- 112
- goals
- 53
- caps
- 46