9Óscar Cardozo
Forward · Club Libertad
- born
- 1983
- apps
- 723
- goals
- 325
- caps
- 58
César Cáceres Cañete
Midfielder · Club Nacional
- born
- 1977
- apps
- 387
- goals
- 81
- caps
- 2
Delio Toledo
Defender · Club Atlético 3 de Febrero
- born
- 1976
- apps
- 373
- goals
- 21
- caps
- 35

Edgar Robles
Midfielder · Sportivo Luqueño
- born
- 1977
- apps
- 372
- goals
- 32
- caps
- 5
12Anthony Domingo Silva
Goalkeeper · Cerro Porteño
- born
- 1984
- apps
- 366
- goals
- 0
- caps
- 21
Domingo Salcedo
Midfielder · Club Sol de América
- born
- 1983
- apps
- 313
- goals
- 18
- caps
- 5
Roberto Gamarra
Forward · Club Rubio Ñu
- born
- 1981
- apps
- 281
- goals
- 264
- caps
- –
Christian René Martínez
Defender · PPSM Sakti Magelang
- born
- 1977
- apps
- 273
- goals
- 9
- caps
- –
Jorge Torales
Forward · Estudiantes de Río Cuarto
- born
- 1984
- apps
- 239
- goals
- 61
- caps
- 1
Gilberto Velásquez
Defender · Tacuary Football Club
- born
- 1983
- apps
- 238
- goals
- 13
- caps
- 5
15activeÉric Ramos
Midfielder · Neftchi Baku PFC
- age
- 39
- apps
- 209
- goals
- 5
- caps
- 5
Juan Ramón Jara
Full-back · Portuguesa FC
- born
- 1970
- apps
- 202
- goals
- 4
- caps
- 17
David Ariel Mendieta Chávez
Midfielder · Deportivo Cali
- age
- 40
- apps
- 201
- goals
- 32
- caps
- 3
Joel Zayas
Goalkeeper · Club Atlético 3 de Febrero
- born
- 1977
- apps
- 193
- goals
- 0
- caps
- 1
activeGastón Lezcano
Midfielder · O'Higgins F.C.
- age
- 40
- apps
- 188
- goals
- 57
- caps
- –
Henry Lapczyk
Goalkeeper · Club Real Potosí
- born
- 1978
- apps
- 177
- goals
- 0
- caps
- 1
Richard Gómez
Midfielder · Club 12 de Octubre
- born
- 1972
- apps
- 177
- goals
- 3
- caps
- 4
Leonardo Migliónico
Defender · Club Atlético 3 de Febrero
- born
- 1980
- apps
- 175
- goals
- 9
- caps
- –
César Llamas
Midfielder · Club Atlético 3 de Febrero
- age
- 41
- apps
- 171
- goals
- 16
- caps
- –

Diego Balbinot
Defender · Valletta F.C.
- born
- 1984
- apps
- 161
- goals
- 9
- caps
- –
Jorge Valdez
Defender · Club Atlético 3 de Febrero
- born
- 1974
- apps
- 159
- goals
- 6
- caps
- 1
Fidencio Oviedo
Midfielder · Cerro Porteño
- age
- 39
- apps
- 156
- goals
- 4
- caps
- –
Casiano Delvalle
Forward · Club Atlético 3 de Febrero
- born
- 1970
- apps
- 148
- goals
- 73
- caps
- 3
Hugo Iriarte
Defender · Club Social y Atlético Guillermo Brown
- born
- 1982
- apps
- 141
- goals
- 3
- caps
- –
Fredy Vera
Defender · Club Sol de América
- age
- 40
- apps
- 137
- goals
- 14
- caps
- –
William Dorneles Shuster
Centre-back · Grêmio FBPA
- age
- 39
- apps
- 134
- goals
- 6
- caps
- –
Julio Aguilar
Forward · Club Deportivo Capiatá
- age
- 40
- apps
- 131
- goals
- 32
- caps
- 1
Milton Benítez
Forward · Sportivo Luqueño
- age
- 40
- apps
- 125
- goals
- 12
- caps
- –
Rodrigo Burgos
Midfielder · Talleres de Córdoba
- age
- 37
- apps
- 115
- goals
- 4
- caps
- 8
Miguel Ángel Cuéllar
Forward · Club Rubio Ñu
- born
- 1982
- apps
- 114
- goals
- 41
- caps
- –
Hugo Lusardi
Midfielder · Club Nacional
- born
- 1982
- apps
- 111
- goals
- 23
- caps
- –
Juan Cardozo
Defender · Independiente F.B.C.
- born
- 1974
- apps
- 110
- goals
- 2
- caps
- 2
Jorge Salinas
Midfielder · Club Olimpia
- age
- 34
- apps
- 105
- goals
- 17
- caps
- 1
Rogerio Leichtweis
Forward · Club Libertad
- age
- 38
- apps
- 101
- goals
- 26
- caps
- –
Pablo Caballero Cáceres
Forward · Boca Unidos
- born
- 1972
- apps
- 93
- goals
- 25
- caps
- –

Matías Di Gregorio
Defender · CA Pinto
- born
- 1986
- apps
- 86
- goals
- 11
- caps
- –
Richard Salinas
Full-back · Club Olimpia
- age
- 38
- apps
- 86
- goals
- 1
- caps
- 15
Regis de Souza
Forward · The Strongest
- born
- 1982
- apps
- 85
- goals
- 33
- caps
- –
Damián Steinert
Central midfielder · Club Atlético 3 de Febrero
- born
- 1986
- apps
- 84
- goals
- 5
- caps
- –
Justo Jacquet
Defender · Club Presidente Hayes
- born
- 1961
- apps
- 80
- goals
- 4
- caps
- 40
Hugo Santacruz
Forward · Club Sol de América
- age
- 37
- apps
- 72
- goals
- 20
- caps
- –
Fernando Oliveira De Avila
Forward · Ayacucho FC
- born
- 1984
- apps
- 63
- goals
- 11
- caps
- –
Angel Antar
Defender · Galatasaray S.K.
- born
- 1972
- apps
- 61
- goals
- 2
- caps
- 2
4activeGustavo Mencia
Full-back · Paraguay men's
- age
- 38
- apps
- 59
- goals
- 6
- caps
- –
Arnaldo Castorino
Forward · Club Nacional
- age
- 39
- apps
- 49
- goals
- 15
- caps
- –
Rafael dos Santos
Midfielder · Esporte Clube São Bento
- born
- 1983
- apps
- 46
- goals
- 2
- caps
- –
Édgar Zaracho
Midfielder · Club General Díaz
- age
- 37
- apps
- 40
- goals
- 2
- caps
- –
Paolo Ortíz
Goalkeeper · Club General Caballero
- age
- 41
- apps
- 36
- goals
- 0
- caps
- –