
Elías Figueroa
Centre-back · Club Social y Deportivo Colo-Colo
- born
- 1946
- apps
- 838
- goals
- 40
- caps
- 47

José Luis Chilavert
Goalkeeper · Club Atlético Vélez Sarsfield
- born
- 1965
- apps
- 791
- goals
- 67
- caps
- 74

Julio Abbadie
Forward · Club Atlético Peñarol
- born
- 1930
- apps
- 649
- goals
- 175
- caps
- 26

Diego Forlán
Forward · Kitchee SC
- born
- 1979
- apps
- 637
- goals
- 258
- caps
- 112

Néstor Gonçalves
Midfielder · Uruguay men's
- born
- 1936
- apps
- 624
- goals
- 0
- caps
- 50
11Maxi Rodriguez
Central midfielder · Newell's Old Boys
- born
- 1981
- apps
- 620
- goals
- 182
- caps
- 64
2Maxi Pereira
Full-back · Club Atlético River Plate
- born
- 1984
- apps
- 617
- goals
- 46
- caps
- 125
8Carlos Sánchez
Central midfielder · C.A. Rentistas
- born
- 1984
- apps
- 594
- goals
- 94
- caps
- 38

Lorenzo Fernández
Midfielder · Club Atlético Peñarol
- born
- 1900
- apps
- 574
- goals
- 35
- caps
- 31

José Piendibene
Forward · Uruguay men's
- born
- 1890
- apps
- 546
- goals
- 273
- caps
- 40

Leônidas
Forward · São Paulo FC
- born
- 1913
- apps
- 546
- goals
- 497
- caps
- 19

Alcides Ghiggia
Position unrecorded · Danubio F.C.
- born
- 1926
- apps
- 519
- goals
- 62
- caps
- 17
17Marcelo Zalayeta
Forward · Club Atlético Peñarol
- born
- 1978
- apps
- 509
- goals
- 139
- caps
- 55
15Diego Pérez
Midfielder · Bologna F.C. 1909
- born
- 1980
- apps
- 507
- goals
- 17
- caps
- 95

Cristian Rodríguez
Attacking midfielder · Plaza Colonia
- born
- 1985
- apps
- 505
- goals
- 74
- caps
- 119
Roy Myers
Inside forward · Asociación Deportiva Santa Bárbara
- born
- 1969
- apps
- 497
- goals
- 71
- caps
- 45
22Darío Rodríguez
Full-back · Club Atlético Peñarol
- born
- 1974
- apps
- 485
- goals
- 31
- caps
- 51

Pablo Bengoechea
Midfielder · Club Atlético Peñarol
- born
- 1965
- apps
- 485
- goals
- 134
- caps
- 43
11activeAbel Hernández
Forward · Club Atlético Peñarol
- age
- 36
- apps
- 478
- goals
- 170
- caps
- 40
José Oscar Herrera
Defender · Club Atlético Peñarol
- born
- 1965
- apps
- 478
- goals
- 49
- caps
- 56
Jorge Horacio Serna
Forward · Fortaleza Fútbol Club
- born
- 1979
- apps
- 473
- goals
- 195
- caps
- 4

Guillermo Giacomazzi
Midfielder · A.C. Perugia Calcio
- born
- 1977
- apps
- 468
- goals
- 52
- caps
- 17
Rubén Umpiérrez
Midfielder · Paris FC
- born
- 1956
- apps
- 468
- goals
- 96
- caps
- 5
Beto Acosta
Forward · União Agrícola Barbarense Futebol Clube
- born
- 1977
- apps
- 458
- goals
- 154
- caps
- –
55Pablo Gabriel García
Midfielder · Xanthi F.C.
- born
- 1977
- apps
- 451
- goals
- 20
- caps
- 72
Gabriel Cedrés
Forward · Deportivo Maldonado
- born
- 1970
- apps
- 450
- goals
- 95
- caps
- 28

Rubén Paz
Midfielder · Godoy Cruz Antonio Tomba
- born
- 1959
- apps
- 449
- goals
- 111
- caps
- 45
11activeGastón Ramírez
Midfielder · Boston River
- age
- 36
- apps
- 446
- goals
- 61
- caps
- 46
Richard Núñez
Forward · Rampla Juniors Football Club
- born
- 1976
- apps
- 445
- goals
- 158
- caps
- 9

Paolo Montero
Centre-back · Club Atlético Peñarol
- born
- 1971
- apps
- 441
- goals
- 13
- caps
- 67

Juan Alberto Schiaffino
Midfielder · AS Roma
- born
- 1925
- apps
- 440
- goals
- 146
- caps
- 25
Mario Guerrero
Defender · Fort Lauderdale Strikers
- born
- 1977
- apps
- 440
- goals
- 14
- caps
- 87
Arnulfo Valentierra
Midfielder · Once Caldas
- born
- 1974
- apps
- 439
- goals
- 118
- caps
- 11

Walter Pandiani
Forward · FC Lausanne-Sport
- born
- 1976
- apps
- 438
- goals
- 135
- caps
- 4
Marcelo Tejera
Midfielder · Liverpool F.C. (Montevideo)
- born
- 1973
- apps
- 427
- goals
- 68
- caps
- 5
8Xisco
Forward · CD Atlético Baleares
- born
- 1986
- apps
- 427
- goals
- 136
- caps
- 11
2activeAlejandro Damián González
Full-back · Club Oriental de Fútbol
- age
- 38
- apps
- 423
- goals
- 6
- caps
- 7

Antonio Pacheco D'Agosti
Forward · Club Atlético Peñarol
- born
- 1976
- apps
- 423
- goals
- 153
- caps
- 12

Luis Cubilla
Central midfielder · Defensor Sporting Club
- born
- 1940
- apps
- 413
- goals
- 103
- caps
- 38

Gonzalo de los Santos
Midfielder · Club Atlético Peñarol
- born
- 1976
- apps
- 409
- goals
- 22
- caps
- 33
Leonardo Fabio Moreno
Forward · Club Celaya
- born
- 1973
- apps
- 409
- goals
- 146
- caps
- 4
José Zalazar
Midfielder · Albacete Balompié
- born
- 1963
- apps
- 397
- goals
- 105
- caps
- 33
Darío Silva
Forward · Portsmouth F.C.
- born
- 1972
- apps
- 388
- goals
- 123
- caps
- 49
Adrián Berbia
Goalkeeper · Boston River
- born
- 1977
- apps
- 386
- goals
- 0
- caps
- 2
Cristian González Aidinovich
Defender · Club Atlético River Plate
- born
- 1976
- apps
- 384
- goals
- 14
- caps
- 8
Mariano Bogliacino
Midfielder · Plaza Colonia
- born
- 1980
- apps
- 383
- goals
- 55
- caps
- –
Juan Guillermo Castillo
Goalkeeper · Boyacá Patriotas
- born
- 1978
- apps
- 381
- goals
- 0
- caps
- 13
Robert Dante Siboldi
Goalkeeper · Gavilanes de Nuevo Laredo
- born
- 1965
- apps
- 381
- goals
- 0
- caps
- 34